Senior/Principal Scientist, Innate Cellular Immunopharmacology

Compass Therapeutics
Cambridge, MA

Compass Therapeutics is a fully-integrated drug discovery and development company focused on manipulating the immune system to treat human disease using our proprietary Targeted Immunomodulation™ platform. Compass is initially focused on developing cures for cancer by comprehensively drugging the entire tumor-immune synapse with combination therapies. Novel scientific insights are validated and explored deeply inside our labs before Compass pursues the best
proprietary combinations of therapeutics into human clinical trials.

Compass has attracted $170M in Series A financing to fund our ambitious plan to build a fullyintegrated biopharmaceutical company from the ground up. Our investors are among the most sophisticated venture capitalists in the industry who exemplify our philosophy of building long term economic value through our therapeutic pipeline. They include OrbiMed Advisors, F-Prime Capital, Borealis Ventures, Thiel Capital, Cowen Private Investments, GV, and Alexandria Real Estate Ventures.

Our Translational Immunology and Immunopharmacology group is seeking a Senior/Principal Scientist, Innate Cellular Immunpharmacology to work hands-on at our Cambridge, MA site.

Principal responsibilities:

• Develop cell-based assays for characterization of NK and myeloid cell modulating drugs for immuno-oncology
• Lead ‘from the bench’, providing direct supervision to 2-3 Scientists/Associate Scientists
• Oversee all aspects of assay design, optimization, validation, and implementation
• Cure cancer by leading from the bench.

Preferred Qualifications:

• Highly knowledgeable immunologist with a proven track record in the field of immunooncology (industry experience highly preferred)
• Extensive experience in the isolation, culture, and functional characterization of primary human innate immune cells, specifically NK cells
• Ability to engineer NK cell lines (e.g., NK-92) and tumor cell lines to express receptors/ligands of interest
• Creativity to design complex assays that address target-specific biology
• Expertise in the measurement and analysis of NK cell assay readouts: proliferation, cytokine production, FACS-based immunophenotyping, mRNA profiling, cytolysis, etc.
• Highly skilled with NK cell killing assays
• Expert knowledge of NK cell biology and regulatory mechanisms
• Experience developing high-throughput assay formats is highly desirable
• Research experience with myeloid cells (macrophages, neutrophils, MDSC) is a plus
• Expertise in creative thinking and multitasking with strong communication skills and comfort in a fast-paced, multinational work environment

Basic Qualifications:

• Ph.D. with 6+ years or M.S. with 8+ years relevant experience

We believe that science is bigger than any one person. Our legacy is what we achieve together. To that
end, Compass Therapeutics offers individually-tailored compensation packages which include
competitive cash compensation, meaningful equity participation, comprehensive healthcare and
adoption benefits, continuous career development, sabbatical programs, education reimbursement
and many other benefits aligned with our philosophy of putting our team first. Our labs are located at
245 First Street, Cambridge, MA.

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