Laboratory of Complement Research and the Immunology Center
National Heart, Lung and Blood Institute
National Institutes of Health (NIH)
Department of Health and Human Services
Dr. Claudia Kemper’s laboratory, which is located in the Laboratory of Complement Research and the Immunology Center, National Heart, Lung and Blood Institute (NHLBI), NIH, is recruiting a postdoctoral researcher to work in the area of immunology and cell biology. Our laboratory focuses on the role of autocrine and intracellular complement in the regulation of innate and adaptive immune responses. We have previously shown that intracellular complement activation is critical to the normal induction and contraction of Th1 responses via regulation of nutrient influx and metabolic activity in CD4+ T cells and that deviations in this ‘pathways’ underlie autoimmune disease (Liszewski et al., Immunity, 2013; Kolev et al., Immunity, 2015; Arbore et al., Science, 2016).
We are now seeking a new member for our team helping us to define the molecular pathways by which intracellular complement regulates immunity in health and disease – with an initial focus on CD4+ and CD8+ T cells and monocytes/macrophages. The laboratory encompasses projects ranging from elucidating physiological and disease mechanisms to signal transduction, molecular mechanisms of gene regulation, and assessment of metabolic pathways driving cell effector functions. State-of-the-art methodologies are used in human and murine systems, including in vitro and in vivo (autoimmune disease and infection models) approaches utilizing ChIP-Seq, RNA-Seq, CyTOF and intravital imaging.
The ideal candidate will have a reasonable level of independence, be innovative and interactive, and will have a strong background in immunology and immunological methods, ideally in T cell biology and/or innate sensor systems (complement, inflammasomes) and/or cell metabolism using mouse and human cellular systems. The candidate must have received a Ph.D. and/or an M.D. degree. The candidate will be supported with the excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH, by a number of national and international collaborators and by an engaged and collaborative atmosphere in the Kemper laboratory.
To apply, email your curriculum vitae and names and contact information for three references to
Dr. Claudia Kemper
Chief, Laboratory of Complement Research
9000 Rockville Pike, Bethesda
DHHS/NIH is an Equal Opportunity Employer