LABORATORY OF TYLER CURIEL AT UT HEALTH SCIENCE CENTER
SAN ANTONIO, TX
- ROLE OF CELL-INTRINSIC PD-L1 AND PD-1 IN CARCINOMAS. This is an NIH-funded, ongoing project to understand mechanisms and consequences of tumor cell-intrinsic PD-L1 and PD-1 in cancer immunopathogenesis and response to immunotherapies based on αPD-L1 or αPD-1.
- MICROENVIRONMENTAL FACTORS IN CANCER IMMUNOTHERAPY RESPONSES. This is the continuation of ongoing studies using three orthotopic models (B16 melanoma in skin, ID8agg ovarian cancer in peritoneum and MB49 bladder cancer in bladder) to understand how local factors interact with distinct tumors to affect immunotherapy and disease progression.
- Il-2 SIGNALS IN CANCER IMMUNOTHERAPY. This is an Ovarian Cancer Research Foundation Alliance-funded relatively new venture to understand how IL-2 signals on effector T cells versus regulatory T cells affect tumor pathogenesis and can be used to improve anti-tumor immunity.
- AGE EFFECTS IN CANCER IMMUNOTHERAPY. Cancer is a disease of the age but models generally use young hosts. This is an Owens Foundation-funded project to understand age effects on cancer immunotherapy building on our prior discoveries.
Our laboratory is large and active and has its own flow cytometry analytic and sorting hardware. We use mouse and human models to understand effects and benefit from a wide range of collaborations around the world. San Antonio is the sixth largest US city yet has a small town feel and low cost of living. Life is relatively hassle free.
Post-doctoral positions are generally for 2-3 years and are available immediately. Please contact Tyler Curiel (firstname.lastname@example.org) for additional information or to meet at AAI.
UTHSA is an equal opportunity employer.